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Keywords
Astrocyte, glutamate, excitotoxicity, thiamine, stroke,
manganese, cerebral ischemia, oxidative stress, brain trauma,
hepatic failure.
Research Interests
Study of the role of astrocytes in neurological disease,
with a major emphasis on glutamate transporter regulation in
relation to excitotoxicity.
Study of the involvement of these cells in the pathophysiology of
traumatic brain injury, vitamin B1 (thiamine) deficiency, focal
cerebral ischemia, hepatic encephalopathy and manganese
neurotoxicity using human autopsy material and animal and cell
culture models of the disorders.
Established techniques in the laboratory include the use of
RT-PCR, real-time PCR, immunoblotting, cerebral microdialysis,
HPLC, autoradiography, FACS, and fluorescence-based
immunohistochemistry.
Publications
Publications indexed on PubMed
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